FKK6 is a selective agonist for pregnane X receptor (PXR) with an EC50 of 1.2 µM. FKK6 exhibits good affinity with plasma proteins, and good metabolic metabolism in human microsomes. FKK6 inhibits PXR-related NF-kappaB signaling pathway, inhibits the expression of inflammatory factors, and exhibits anti-inflammatory activity against DSS (HY-116282)-induced colitis in mouse model[1][2].
Molekulargewicht:
402.47
Reinheit:
99.14
CAS Nummer:
[2238839-34-2]
Formel:
C23H18N2O3S
Target-Kategorie:
Interleukin Related,NF-kappaB
Anwendungsbeschreibung:
MCE Product type: Reference compound
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