Avitinib (Abivertinib) maleate dihydrate is a third-generation, irreversible and orally active selective EGFR inhibitor, with IC50 values of 0.18 nM, 0.18 nM, 7.68 nM and against EGFR L858R, EGFR T790M and wild-type EGFR. Avitinib maleate dihydrate is also a BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma. Avitinib maleate dihydrate shows anticancer effects[1][2].
Molekulargewicht:
639.63
CAS Nummer:
[1822357-78-7]
Formel:
C30H34FN7O8
Target-Kategorie:
Apoptosis,Btk,EGFR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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