Aurora-A ligand 1 is a high-affinity and specific Aurora-A inhibitor with a dissociation constant (Kd) value of 0.85 nM. Aurora-A ligand 1 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC Aurora-A degraders with antitumor activity. Aurora-A ligand 1 can be used for the synthesis of HLB-0532259 (HY-168439). HLB-0532259 shows anti-tumor activity against neuroblastoma[1].
Molekulargewicht:
393.44
Reinheit:
98.75
CAS Nummer:
[2541626-73-5]
Formel:
C21H23N5O3
Target-Kategorie:
Aurora Kinase,CDK,Ligands for Target Protein for PROTAC
Anwendungsbeschreibung:
MCE Product type: Reference compound
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