SJ46421 is a (+)-JQ-1 (HY-13030) based KLHDC2-BRD3 PROTAC protein degrader. SJ46421 induces cooperative ternary complexes with KLHDC2 and BRD3BD2, with an IC50 of 7.8 nM. SJ46421 selectively inhibits KLHDC2 substrate ubiquitylation. SJ46421 promotes polyubiquitylation of the BD2 domain from BRD2, BRD3, or BRD4. SJ46421 possesses poor cell permeability. (Pink: ligand for target protein (HY-13030), Black: linker (HY-20797), Blue: E3 ligase ligand (HY-168536))[1].
Molekulargewicht:
837.41
Formel:
C42H41ClN8O5S2
Target-Kategorie:
Epigenetic Reader Domain,PROTACs
Anwendungsbeschreibung:
MCE Product type: Reference compound
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