PROTAC K-Ras Degrader-5, CAS [[3052745-16-8]]

Produktübersicht

• Artikelname: PROTAC K-Ras Degrader-5, CAS [[3052745-16-8]]
• Artikelnummer: MCE-HY-168669
• Hersteller Artikelnummer: HY-168669
• Alternativnummer: MCE-HY-168669-10MG,MCE-HY-168669-5MG,MCE-HY-168669-1MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

PROTAC K-Ras Degrader-5 is a cereblon-based K-Ras PROTAC degrader with a DC50 of G12D. PROTAC K-Ras Degrader-5 recruits KRASG12D to the cereblon E3 ubiquitin ligase complex for ubiquitination and subsequent proteasomal degradation. PROTAC K-Ras Degrader-5 suppresses pERK levels downstream of KRASG12D degradation in cancer cells. PROTAC K-Ras Degrader-5 reduces proliferation of cancer cells. PROTAC K-Ras Degrader-5 induces caspase 3/7 activity and cPARP, markers of apoptosis, in pancreatic cancer spheroids and tumors. PROTAC K-Ras Degrader-5 can be used for the research of pancreatic cancer and colorectal cancer[1].

Produkteigenschaften

• Molekulargewicht: 1025.17
• Reinheit: 97.84
• CAS Nummer: [3052745-16-8]
• Formel: C57H63F3N10O5
• Target-Kategorie: Caspase,ERK,PROTACs,Ras

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound1