V1a/V2 antagonist 1 (Compound 18j) is an orally active dual V1a and V2 receptor antagonist with high binding affinity for both receptors (Ki: 0.13 nM for hV1a, 0.53 nM for hV2 and 0.5 nM for mV1a, IC50: 2.2 nM for hV1a). V1a/V2 antagonist 1 inhibits Oxytocin (HY-17571)-induced scratching behavior in mice[1].
Molekulargewicht:
479.96
Formel:
C25H26ClN5O3
Target-Kategorie:
Vasopressin Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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