RD-23 is an orally active and selective RET PROTAC degrader. RD-23 promotes ubiquitination and degradation of RETG810C mutation, with a DC50 value of 11.7 nM. RD-23 inhibits the activation of downstream Shc signaling and induces Apoptosis. RD-23 can be used for the research of RET-related cancers (Pink: RET ligand-2 (HY-168868), Blue: E3 ligase CRBN ligand, Black: linker)[1].
Molekulargewicht:
913.08
CAS Nummer:
[3053537-06-4]
Formel:
C52H56N12O4
Target-Kategorie:
Apoptosis,PROTACs,RET
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
