EXQ-2d is the inhibitor for tankyrase and inhibits TNKS1 and TNKS2 with an IC50 of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86). EXQ-2d inhibits WNT/beta-catenin signaling pathway with IC50 of 515 nM. EXQ-2d exhibits anti-proliferative activity in cancer cells COLO 320DM and RKO with GI50 of 4.9 µM and 77 µM[1].
Molekulargewicht:
323.35
Formel:
C18H17N3O3
Target-Kategorie:
PARP,Wnt,beta-catenin
Anwendungsbeschreibung:
MCE Product type: Reference compound
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