CB1R agonist 1 is a potent, CNS-penetrant, and selective Cannabinoid-1 receptor (CB1R) agonist with a Ki of 0.95 nM, modulating Gi/o signaling. CB1R agonist 1 exhibits high selectivity over CB2R and other off-target GPCRs, including GPR55, GPR18, and GPR119. CB1R agonist 1 induces analgesia and hypothermia, and potentiates opioid analgesia in mice. CB1R agonist 1 can be used for the research of pain[1].
Molekulargewicht:
437.44
Formel:
C20H18F3N3O3S
Target-Kategorie:
Cannabinoid Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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