MS41, CAS [[2768610-97-3]]
Artikelnummer:
MCE-HY-169093
| Artikelname: |
MS41, CAS [[2768610-97-3]] |
| Artikelnummer: |
MCE-HY-169093 |
| Hersteller Artikelnummer: |
HY-169093 |
| Alternativnummer: |
MCE-HY-169093-5MG,MCE-HY-169093-25MG,MCE-HY-169093-10MG |
| Hersteller: |
MedchemExpress |
| Kategorie: |
Biochemikalien |
| MS41 is a selective eleven-nineteen leukemia (ENL) PROTAC degrader, with DC50s of 3.50 nM (MV4,11), 2.84 nM (SEMK2), 3.03 nM (Jurkat), and 26.58 nM (KASUMI1), respectively. MS41 effectively inhibits the growth of ENL-dependent leukemia cells, induces G1 cell cycle arrest and increases apoptosis. MS41 reduces the chromatin occupancy of ENL-associated transcription elongation machinery, and suppresses oncogenic gene expression and leukemia progression. Red: ENL ligand (HY-169094). Black: linker (HY-W105744). Blue: VHL ligand (HY-112078)[1]. |
| Molekulargewicht: |
1031.27 |
| Reinheit: |
98.97 |
| CAS Nummer: |
[2768610-97-3] |
| Formel: |
C56H70N8O9S |
| Target-Kategorie: |
Apoptosis,Epigenetic Reader Domain,PROTACs |
| Anwendungsbeschreibung: |
MCE Product type: Reference compound |
