Neuroprotective agent 5 (compound 28) is a brain permeabilizing agent with anti-neuritis, anti-oxidative damage and neuroprotective effects. Neuroprotective agent 5 exhibits a potent NO inhibitory effect (EC50=0.49 µM), inhibits the release of proinflammatory factors PGE2 and TNF-alpha, downregulates the expression of iNOS and COX-2 proteins, and promotes the polarization of BV-2 cells from the proinflammatory M1 phenotype to the anti-inflammatory M2 phenotype. In addition, Neuroprotective agent 5 can also inhibit acetylcholinesterase (AChE) activity and Abeta42 aggregation in a dose-dependent manner. Neuroprotective agent 5 can be used for the study of Alzheimers disease[1].
Molekulargewicht:
291.28
Formel:
C14H14FN3O3
Target-Kategorie:
Amyloid-beta,Cholinesterase (ChE),COX,NO Synthase
Anwendungsbeschreibung:
MCE Product type: Reference compound1
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
