Crobenetine (BIII-890), a benzomorphan derivative, is a potent, selective, and highly use-dependent Na+ channel blocker. Crobenetine displaces [3H]BTX from site 2 of the Na+ channel (IC50=49 nM) in rat brain synaptosomes, yet exhibits only low binding affinity for other receptors and ion channels. Crobenetine protects brain tissue from the deleterious effects of focal cerebral ischemia in rodents[1].
Molekulargewicht:
379.54
CAS Nummer:
[221019-25-6]
Formel:
C25H33NO2
Target-Kategorie:
Sodium Channel
Anwendungsbeschreibung:
MCE Product type: Reference compound
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