HDACs/EZH2-IN-1 (Compound 22a) is a HDACs/EZH2 inhibitor (EZH2 Y641N inhibition rate at 50 nM: 98%), with selective inhibition against HDAC1 and HDAC6 (IC50: 0.23 µM and 0.07 µM, respectively). HDACs/EZH2-IN-1 exerts a antiproliferative effect on diffuse large B-cell lymphoma cells harboring an EZH2 mutation and on various acute myeloid leukemia cells. HDACs/EZH2-IN-1 has the ability to induce cell differentiation and Apoptosis[1].
Molekulargewicht:
626.54
Formel:
C29H36BrN7O4
Target-Kategorie:
Apoptosis,HDAC,Histone Methyltransferase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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