PDE1-IN-9 (Compound 7a) is a selective inhibitor for phosphodiesterase 1 (PDE1), that inhibits PDE1C with an IC50 of 11 nM. PDE1-IN-9 reduces mRNA expression of IL-1beta, IL-6, TNF-alpha and iNOS, inhibits the production of nitric oxide (NO) and reactive oxygen species (ROS). PDE1-IN-9 exhibits good metabolic stability in rat liver microsomes[1].
Molekulargewicht:
441.56
Reinheit:
98.74
CAS Nummer:
[2982945-41-3]
Formel:
C28H31N3O2
Target-Kategorie:
Interleukin Related,NO Synthase,Phosphodiesterase (PDE),Reactive Oxygen Species (ROS)
Anwendungsbeschreibung:
MCE Product type: ADC Related
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten