Sitravatinib (malate), CAS [[2244864-88-6]] Preis auf Anfrage
Artikelnummer:
MCE-HY-16961A
| Artikelname: |
Sitravatinib (malate), CAS [[2244864-88-6]] Preis auf Anfrage |
| Artikelnummer: |
MCE-HY-16961A |
| Hersteller Artikelnummer: |
HY-16961A |
| Alternativnummer: |
MCE-HY-16961A-1UNIT |
| Hersteller: |
MedchemExpress |
| Kategorie: |
Biochemikalien |
| Alternative Synonym: |
MGCD516 (malate), MG-516 (malate) |
| Sitravatinib malate (MGCD516 malate) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively[1]. Sitravatinib malate shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment[2]. |
| Molekulargewicht: |
763.76 |
| CAS Nummer: |
[2244864-88-6] |
| Formel: |
C37H35F2N5O9S |
| Target-Kategorie: |
c-Kit,Discoidin Domain Receptor,FLT3,Trk Receptor,VEGFR |
| Anwendungsbeschreibung: |
MCE Product type: Reference compound |
