Darolutamide, CAS [[1297538-32-9]]

Produktübersicht

• Artikelname: Darolutamide, CAS [[1297538-32-9]]
• Artikelnummer: MCE-HY-16985
• Hersteller Artikelnummer: HY-16985
• Alternativnummer: MCE-HY-16985-10MMX1ML,MCE-HY-16985-5MG,MCE-HY-16985-100MG,MCE-HY-16985-50MG,MCE-HY-16985-10MG,MCE-HY-16985-25MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: ODM-201, BAY-1841788

Produktbeschreibung

Darolutamide (ODM-201) is an orally active competitive androgen receptor (AR) antagonist. Darolutamide has a Ki of 11 nM for rat wild-type AR (wtAR) and IC50 of 26 nM for human wild-type AR (hAR)-mediated transcriptional activation[1]. Darolutamide inhibits testosterone-induced AR nuclear translocation and transcriptional activation[1]. Darolutamide exerts selective effects on AR-positive cells by inhibiting AR-dependent signaling pathways, and its active metabolite retains full antagonistic activity against AR mutants[1]. Darolutamide can be used for the research of prostate cancer, including androgen receptor-dependent prostate cancer[1].

Produkteigenschaften

• Molekulargewicht: 398.85
• Reinheit: 99.73
• CAS Nummer: [1297538-32-9]
• Formel: C19H19ClN6O2
• Target-Kategorie: Androgen Receptor

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound