Keap1-IN-1 (Compound 27) is the inhibitor for Keap1, that covalently modifys the Cys151 site in the BTB domain of KEAP1, and interfers with the interaction between Keap-Nrf. Keap1-IN-1 upregulates the mRNA expression of the antioxidant stress element (ARE)-dependent gene NQO1 with an EC50 of 160 nM. Keap1-IN-1 exhibits cytotoxicity in cell U2OS with an EC50 of 527 nM[1].
Molekulargewicht:
531.43
Formel:
C17H21Cl2N2O5PS3
Target-Kategorie:
Keap1-Nrf2,Quinone Reductase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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