PROTAC AR Degrader-8, CAS [[3044108-04-2]]

Produktübersicht

• Artikelname: PROTAC AR Degrader-8, CAS [[3044108-04-2]]
• Artikelnummer: MCE-HY-170329
• Hersteller Artikelnummer: HY-170329
• Alternativnummer: MCE-HY-170329-5MG,MCE-HY-170329-10MMX1ML,MCE-HY-170329-25MG,MCE-HY-170329-50MG,MCE-HY-170329-100MG,MCE-HY-170329-10MG,MCE-HY-170329-1MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

PROTAC AR Degrader-8 is the PROTAC degrader for androgen receptor (AR) that degrades AR-FL with DC50s of 0.018 µM and 0.14 µM in 22Rv1 cell and LNCaP cell, degrades AR-V7 with DC50 of 0.026 µM in 22Rv1 cell. PROTAC AR Degrader-8 inhibits the proliferation of cancer cell 22Rv1 and LNCaP with IC50 values of 0.038 µM and 1.11 µM. PROTAC AR Degrader-8 arrests cell cycle at G2/M phase, induces apoptosis in 22Rv1 cell. PROTAC AR Degrader-8 exhibits anticancer efficacy in mouse and zebrafish model. PROTAC AR Degrader-8 can be used for the research of prostate cancer, castration-resistant prostate cancer[1].

Produkteigenschaften

• Molekulargewicht: 703.78
• Reinheit: 99.98
• CAS Nummer: [3044108-04-2]
• Formel: C40H41N5O7
• Target-Kategorie: Androgen Receptor,Apoptosis,PROTACs

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound