PROTAC AR Degrader-8 (Compound NP18) is the PROTAC degrader for androgen receptor (AR), that degrades AR-FL with DC50 of 0.018 µM and 0.14 µM in 22Rv1 cell and LNCaP cell, degrades AR-V7 with DC50 of 0.026 µM in 22Rv1 cell. PROTAC AR Degrader-8 inhibits the proliferation of cancer cell 22Rv1 and LNCaP with IC50 of 0.038 µM and 1.11 µM. PROTAC AR Degrader-8 arrests cell cycle at G2/M phase, induces apoptosis in 22Rv1 cell. PROTAC AR Degrader-8 exhibits anticancer efficacy in mouse and zebrafish model[1]. (Pink: ligand for target protein AR ligand-33 (HY-170330), Black: linker (HY-W007731), Blue: ligand for E3 ligase Cereblon (HY-14658))
Molekulargewicht:
703.78
Reinheit:
99.98
CAS Nummer:
[3044108-04-2]
Formel:
C40H41N5O7
Target-Kategorie:
Androgen Receptor,Apoptosis,PROTACs
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
