AB3067 is a PROTAC degrader for BET protein, that recruits two different E3 ligase Cereblon and VHL with good affinity (IC50=559 nM for VHL in live HEK293, IC50=190 nM for CRBN in live HEK293), and degrades BRD2, BRD3, BRD4 and CRBN with DC50 of 2.1~2.3, 1.6, 15 and 75 nM, respectively. AB3067 inhibits the proliferation of RKO cell with an EC50 of 111 nM[1]. (Pink: ligand for target protein (HY-131633A), Black: linker (HY-170391), Blue: ligand for E3 ligase VHL (HY-112078) and CRBN(HY-W998346))
Molekulargewicht:
1525.16
Formel:
C74H91ClFN11O17S2
Target-Kategorie:
Epigenetic Reader Domain,PROTACs
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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