LSD1-IN-38 (Compound 23e) is a reversible, orally active inhibitor for lysine specific demethylase 1 (LSD1) with an IC50 of 1.2 nM. LSD1-IN-38 inhibits the proliferation of cancer cells MV4-11, Kasumi-1 and NCI-H526, with IC50 of 5, 4 and 11 nM, respectively. LSD1-IN-38 activates CD86 expression with an EC50 of 0.034 µM, and induces differentiation in MV4 11 cell. LSD1-IN-38 exhibits antitumor efficacy in mouse models[1].
Molekulargewicht:
535.58
Formel:
C30H29F4N5
Target-Kategorie:
Histone Demethylase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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