KAI-11101 is the inhibitor for dual leucine zipper kinase (DLK, MAP3K12) with a Ki of 0.7 nM. KAI-11101 inhibits Paclitaxel (HY-B0015)-induced cJun phosphorylation (IC50=95 nM) and thus inhibits the activation of MAPK pathway. KAI-11101 is blood brain barrier penetrable and can be further investigated for its neuroprotective property[1].
Molekulargewicht:
469.43
Formel:
C21H23F4N5O3
Target-Kategorie:
MAP3K,p38 MAPK
Anwendungsbeschreibung:
MCE Product type: Reference compound
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