ISM012-042, CAS [[2924181-80-4]] Preis auf Anfrage

Produktübersicht

• Artikelname: ISM012-042, CAS [[2924181-80-4]] Preis auf Anfrage
• Artikelnummer: MCE-HY-170522
• Hersteller Artikelnummer: HY-170522
• Alternativnummer: MCE-HY-170522-5MG,MCE-HY-170522-25MG,MCE-HY-170522-50MG,MCE-HY-170522-100MG,MCE-HY-170522-10MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

ISM012-042 is an orally active PHD1 and PHD2 inhibitor with IC50 values of 1.9 and 2.5 nM, respectively. ISM012-042 (2.5 µM) can protect Caco-2 cells from DSS-induced barrier disruption. In lipopolysaccharide (LPS)-induced mouse bone marrow-derived dendritic cells (BMDC), ISM012-042 has anti-inflammatory effects and can dose-dependently reduce the expression of IL-12 subunit IL-12p35 and TNF. ISM012-042 restores intestinal barrier function and alleviates intestinal inflammation in various experimental colitis models. ISM012-042 can be used for intestinal mucosal repair and research into immune diseases[1].

Produkteigenschaften

• Molekulargewicht: 489.53
• CAS Nummer: [2924181-80-4]
• Formel: C25H27N7O4
• Target-Kategorie: HIF/HIF Prolyl-Hydroxylase

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound