SMD-1087 is a PROTAC that selectively targets SMARCA2 (DC50=8 nM, Dmax=89%) and SMARCA4 with a DC50 of 1 µM. SMD-1087 consists of the E3 ligase ligand (S,R,S)-AHPC-Me (blue part) (HY-112078), the target protein ligand SMI-1074 (red part) (HY-170817), and the PROTAC linker (1r,4r)-tert-Butyl 4-(bromomethyl)cyclohexanecarboxylate (black part) (HY-W890392). Among them, its target protein ligand + Linker part corresponds to SMARCA2 Ligand-Linker Conjugate-1 (HY-170829)[1].
Molekulargewicht:
986.70
CAS Nummer:
[3033586-04-5]
Formel:
C56H68ClN7O5S
Target-Kategorie:
PROTACs,SWI/SNF Complex
Anwendungsbeschreibung:
MCE Product type: Reference compound
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