LYG-409 is an orally active degrader of GSPT1. LYG-409 shows excellent anti-acute myeloid leukemia and prostate cancer in vivo with TGI of 94.34% and 104.49%, respectively. LYG-409 inhibits KG-1 cells mediated by the degradation of GSPT1 with an IC50 of 9.50 nM, with a DC50 of 7.87 nM in vitro[1].
Molekulargewicht:
515.44
Reinheit:
98.11
CAS Nummer:
[3053857-55-6]
Formel:
C25H20F3N3O6
Target-Kategorie:
Molecular Glues
Anwendungsbeschreibung:
MCE Product type: Reference compound
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