CX-5279 is an efficient and selective CK2 inhibitor with IC50 values for nCK2 and CK2alpha of 2.73 and 0.91 nM, respectively. CX-5279 is sensitive to mutations at Val66, Ile174, and V66I174AA, with IC50 values of 13.8, 12.5, and 23.35 nM, respectively. CX-5279s inhibitory activity against PIM1 is very weak, with a IC50 value of 8.52 µM. CX-5279 exhibits anti-proliferative activity in various cancer cell lines. CX-5279 can be used for research on cancers such as pancreatic cancer and leukemia[1].
Molekulargewicht:
461.37
CAS Nummer:
[1333382-32-3]
Formel:
C22H15F3N5NaO2
Target-Kategorie:
Casein Kinase
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
