CDKL5/GSK3-IN-1 (Compound 2) is a potent and selectivity chemical probe for CDKL5/GSK3.CDKL5/GSK3-IN-1 has potent inhibition of CDKL5 and GSK3alpha/beta, with IC50 values of 4.6, 24 and 9.5 nM for CDKL5, GSK3beta and GSK3alpha, respectively, in the NanoBRET assay. CDKL5/GSK3-IN-1 can be used for the research of CNS diseases[1].
Molekulargewicht:
349.34
Reinheit:
98.72
CAS Nummer:
[844442-32-6]
Formel:
C16H17F2N5O2
Target-Kategorie:
GSK-3
Anwendungsbeschreibung:
MCE Product type: Reference compound
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