NF-kappaB-IN-19 (Compound 8) is an NF-kappaB inhibitor. NF-kappaB-IN-19 effectively induces DNA damage, promotes the generation of ROS, and induces autophagy and apoptosis through the NF-kappaB signaling pathway in tumor cells. In addition, NF-kappaB-IN-19 can inhibit the levels of VEGF and HIF-1alpha, and exert antiproliferative activity in tumor cells through the PI3K/AKT and STAT-3 pathways. NF-kappaB-IN-19 can effectively overcome cisplatin resistance and has anti-tumor activity[1].
Molekulargewicht:
759.92
Formel:
C24H26Cl3F2N3O4Pt
Target-Kategorie:
Akt,Apoptosis,Autophagy,HIF/HIF Prolyl-Hydroxylase,NF-kappaB,PI3K,Reactive Oxygen Species (ROS),STAT
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
