Soclenicant (BNC210) is an orally active alpha7 nAChR negative alteration modulator (NAM) with no apparent side effects. Soclenicant exhibits acute anxiolytic activity in rodent models of anxiety. Soclenicant inhibits rat and human alpha7 nAChR currents (in stably transfected cell lines) induced by acetylcholine, nicotine, choline, and the a7-specific agonist PNU-282987 (HY-12560A) with IC50 values in the range of 1.2 to 3 µM. Soclenicant can be used in studies of anxiety, trauma, and stressor-related disorders[1][2][3][4].
Molekulargewicht:
418.49
Reinheit:
99.75
CAS Nummer:
[1020634-41-6]
Formel:
C24H26N4O3
Target-Kategorie:
nAChR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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