CSN5-IN-2 (Compound 31) is a CSN5 inhibitor with an IC50 of 0.36 µM. CSN5-IN-2 can increase the level of Cullin 1 neddylation, and downregulate the expression of RAD51 and PD-L1 in cancer cells. CSN5-IN-2 has anti-tumor activity, and its effect is better when combined with Talazoparib (HY-16106)[1].
Molekulargewicht:
538.68
Formel:
C32H38N6O2
Target-Kategorie:
PD-1/PD-L1,RAD51
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
