WEHI-3773 is a VDAC2 ligand and apoptosis (Apoptosis) modulator. WEHI-3773 directly binds to the beta7-beta10 region of VDAC2 and disrupts its interaction with BAX and BAK. WEHI-3773 regulates BAX-mediated apoptosis in BAK-deficient cells by modulating conformational activation of BAX, mitochondrial redistribution, and cytochrome c release. WEHI-3773 overcomes Venetoclax (HY-15531) resistance, resensitizes leukemia cells carrying BAX mutations to BH3 mimetics, and enables long-term clonogenic survival of BAK-deficient cells treated with BH3 mimetics. WEHI-3773 is applicable to research related to acute myeloid leukemia[1][2].
Molekulargewicht:
618.69
Reinheit:
99.89
Formel:
C30H22N10O2S2
Target-Kategorie:
Apoptosis,Bcl-2 Family,VDAC
Anwendungsbeschreibung:
MCE Product type: Natural Products
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
