FGFR-IN-18 (Compound KF7) is a lysine-targeting FGFR covalent inhibitor, with IC50s of: 1.1 nM for FGFR2, 1.3 nM for FGFR1, 31.5 nM for FGFR4. FGFR-IN-18 also has affinity for FGFR3 (inhibition rate of 52% at 10 nM). FGFR-IN-18 covalently modifies Lys485 (an reactive site of FGFRs)[1].
Molekulargewicht:
643.69
Formel:
C32H37N9O6
Target-Kategorie:
FGFR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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