FGT-4 is a folate receptor beta (FR-beta) targeting chimeric molecule. FGT-4 is a TLR7 agonist. FGT-4 facilitates the secretion of iNOS and proinflammatory cytokine IL-6 associated with M1 macrophages and enhances the proliferation of cytotoxic CD8+ T cells. FGT-4 has anti-tumor activity in the 4T1 breast cancer mouse model. FGT-4 can be used for the study of cancer immunity. (Pink: target protein TLR7/8 agonist 1 ligand (HY-103698), black: linker (HY-172936), blue: FR-beta ligand (HY-172935))[1].
Molekulargewicht:
1020.19
Formel:
C50H57N11O9S2
Target-Kategorie:
NO Synthase,PROTACs,Toll-like Receptor (TLR)
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
