LSD1-IN-40 (Compound 9e) is a potent LSD1 inhibitor, with an IC50 of 9.85 nM. LSD1-IN-40 exhibits exceptional selectivity for LSD1 over both MAOs and hERG. LSD1-IN-40 exhibits significant inhibitory activity against leukemia cells (MV-4-11, HL-60, and THP-1 cells). LSD1-IN-40 can induce apoptosis in MV-4-11 cells. LSD1-IN-40 has the potential for the research of acute myeloid leukemia[1].
Molekulargewicht:
506.53
Formel:
C25H20F2N6O2S
Target-Kategorie:
Apoptosis,Histone Demethylase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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