CW-2 Preis auf Anfrage
Artikelnummer:
MCE-HY-173437
| Artikelname: |
CW-2 Preis auf Anfrage |
| Artikelnummer: |
MCE-HY-173437 |
| Hersteller Artikelnummer: |
HY-173437 |
| Alternativnummer: |
MCE-HY-173437-1UNIT |
| Hersteller: |
MedchemExpress |
| Kategorie: |
Biochemikalien |
| CW-2 is a PARP1 PROTAC degrader. CW-2 has potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 µM) and CDDP-resistant cells (A549/CDDP: IC50 = 3.52 µM). CW-2 has synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts antitumor effects by inducing DNA damage, impairing DNA repair, and activating mitochondria-dependent apoptosis (Pink: PARP1 ligand (HY-173441), Blue: E3 CRBN ligand (HY-173439), Black: linker (HY-173440))[1]. |
| Molekulargewicht: |
1157.85 |
| Formel: |
C43H42Cl2FN11O10Pt |
| Target-Kategorie: |
DNA/RNA Synthesis,PARP,PROTACs |
| Anwendungsbeschreibung: |
MCE Product type: Reference compound |
