Loteprednol Etabonate-d3 is the deuterium labeled Loteprednol Etabonate. Loteprednol etabonate (LE) is an orally active soft steroid belonging to a unique class of glucocorticoids. Loteprednol etabonate (LE) exhibits anti-inflammatory activity and has been used in optometry and ophthalmology[1][2][3].