Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride cannot cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6].
Molekulargewicht:
415.74
Reinheit:
99.74
CAS Nummer:
[2250025-93-3]
Formel:
C18H21Cl3N4O
Target-Kategorie:
Dopamine Receptor,Drug Metabolite,mAChR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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