PIM-1/HDAC-IN-2, CAS [[3103925-33-0]] Preis auf Anfrage

Produktübersicht

• Artikelname: PIM-1/HDAC-IN-2, CAS [[3103925-33-0]] Preis auf Anfrage
• Artikelnummer: MCE-HY-174302
• Hersteller Artikelnummer: HY-174302
• Alternativnummer: MCE-HY-174302-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

PIM-1/HDAC-IN-2 is a robust PIM/HDAC inhibitor (IC50 = 0.11 µM in MV4-11cells), which exerts a synergistic antiproliferative effect through a dual mechanism of inhibiting PIM1 kinase and selectively inhibiting HDAC6. PIM-1/HDAC-IN-2 induces cell apoptosis. PIM-1/HDAC-IN-2 remarkably induces the cleavage of PARP, thereby initiating the arrest of the cell cycle in G1 phase and a reduction in S phase. PIM-1/HDAC-IN-2 demonstrates significant anticancer efficacyin the MV4-11 xenograft model without notable toxicity[1].

Produkteigenschaften

• Molekulargewicht: 607.70
• CAS Nummer: [3103925-33-0]
• Formel: C34H37N7O4
• Target-Kategorie: Apoptosis,HDAC,PARP,Pim

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound