WZH-17-002 is a WZH-15-125-based ALK PROTAC degrader with a DC50 of 25 nM. WZH-17-002 enhances activities against Lorlatinib (HY-12215)-resistant ALK compound mutations. WZH-17-002 significantly reduces drug resistance in ALK-fusion non-small cell lung cancer (NSCLC) and inhibits tumor growth in EML4-ALK G1202R/L1196 M xenograft mice model[1]. Pink: ALK ligand (HY-174314), Blue: CRBN ligase ligand (HY-14658), Black: linker (HY-174316)
Molekulargewicht:
1044.97
Formel:
C47H54BrN11O10S
Target-Kategorie:
Akt,Anaplastic lymphoma kinase (ALK),ERK,PROTACs
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
