INNO-220 is an orally active, CRBN-dependent molecular glue degrader targeting CK1alpha. INNO-220 induces cell cycle arrest at G0/G1 phase and triggers apoptosis by degrading CK1alpha. INNO-220 disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, thereby inhibiting NF-kappaB signaling in stimulated T cells and lymphoma cells that harbor an activating mutation in CARD11. INNO-220 provides a new direction for lymphoma research[1].
Molekulargewicht:
400.43
Reinheit:
98.6
CAS Nummer:
[3032576-92-1]
Formel:
C23H20N4O3
Target-Kategorie:
Casein Kinase,MALT1,MDM-2/p53,Molecular Glues
Anwendungsbeschreibung:
MCE Product type: Reference compound
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