SGLT2-IN-2 (Compound E9) is an inhibitor of SGLT2. SGLT2-IN-2 significantly enhances the inhibition of SGLT2, NHE1, and SOD enzyme activity. SGLT2-IN-2 has protective effect on the glucose-free DMEM-induced injured cardiomyocytes. SGLT2-IN-2 significantly improves cardiac function in TAC-induced HF mice and inhibits cardiomyocyte hypertrophy as well as collagen deposition. SGLT2-IN-2 can ameliorate myocardial tissue damage and enhance mitochondrial autophagy in injured cardiomyocytes, thereby increasing survival rates in HF mice[1].
Molekulargewicht:
427.45
Reinheit:
99.57
Formel:
C22H25N3O6
Target-Kategorie:
Autophagy,Na+/H+ Exchanger (NHE),SGLT,SOD
Anwendungsbeschreibung:
MCE Product type: Reference compound
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