MD-4251 Preis auf Anfrage
Artikelnummer:
MCE-HY-174458
| Artikelname: |
MD-4251 Preis auf Anfrage |
| Artikelnummer: |
MCE-HY-174458 |
| Hersteller Artikelnummer: |
HY-174458 |
| Alternativnummer: |
MCE-HY-174458-1UNIT |
| Hersteller: |
MedchemExpress |
| Kategorie: |
Biochemikalien |
| MD-4251 is an orally active MDM2 PROTAC degrader. MD-4251 potently degrades MDM2 in RS4,11 cells (DC50: 0.2 nM) and actives p53. MD-4251 shows strong antiproliferative activity against acute leukemia cells (wild-type p53) with minimal efficacy in mutant type. MD-4251 induces complete tumor regression in RS4,11 xenograft mice model[1]. Pink: MDM2 ligand (HY-130684), Blue: CRBN ligase ligand (HY-W883326), Black: linker |
| Molekulargewicht: |
883.88 |
| Formel: |
C47H53Cl2FN8O4 |
| Target-Kategorie: |
Casein Kinase,IKZF Family,MDM-2/p53,PROTACs |
| Anwendungsbeschreibung: |
MCE Product type: Reference compound |
