PROTAC PI3Kalpha degrader-1

Produktübersicht

• Artikelname: PROTAC PI3Kalpha degrader-1
• Artikelnummer: MCE-HY-174461
• Hersteller Artikelnummer: HY-174461
• Alternativnummer: MCE-HY-174461-100MG,MCE-HY-174461-1MG,MCE-HY-174461-5MG,MCE-HY-174461-10MMX1ML,MCE-HY-174461-10MG,MCE-HY-174461-25MG,MCE-HY-174461-50MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

PROTAC PI3Kalpha degrader-1 is a PI3Kalpha PROTAC degrader (DC50 = 0.08 µM), demonstrating good selectivity for PI3Kalpha degradation over PI3Kbeta, PI3Kgamma, and PI3Kdelta. PROTAC PI3Kalpha degrader-1 effectively degrades PI3Kalpha in a time- and concentration-dependent, over PI3Kbeta, PI3Ky and PI3Kdelta, and potently inhibited the phosphorylation of AKT at the Ser473site. PROTAC PI3Kalpha degrader-1 shows significant in vivo anticancer efficacy in HGC-27 and DOHH2 xenograft models. (Pink: PI3Kalpha ligand : (HY-174798), Blue: E3 ligase CRBN Ligand (HY-10984), Black: Linker, E3 ligase ligand-linker conjugate (HY-W940885))[1].

Produkteigenschaften

• Molekulargewicht: 897.99
• Reinheit: 99.21
• Formel: C46H49F2N7O8S
• Target-Kategorie: PI3K,PROTACs

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound