dASK1 is a selective and cereblon (CRBN)-based PROTAC degrader of apoptosis signal-regulating kinase 1 (ASK1). dASK1 forms a stable ternary complex with ASK1, facilitating ASK1 rapid and sustained degradation via the ubiquitin-proteasome pathway. dASK1 demonstrates potent ASK1 degradation. dASK1 can be used for the research of steatohepatitis[1]. (Structure Note: Pink: ASK1 ligand (HY-174860), Blue: CRBN ligand (HY-10984), Black: linker, E3-linker (HY-174863))
Molekulargewicht:
800.77
CAS Nummer:
[3064086-31-0]
Formel:
C38H38F2N10O8
Target-Kategorie:
ASK1,PROTACs
Anwendungsbeschreibung:
MCE Product type: Reference compound
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