PZ671 is a potent Bcl-xL PROTAC degrader with an IC50 of 1.3 nM (MOLT-4 cells) and a DC50 of 0.9 nM (Bcl-xL). PZ671 induces apoptosis in MOLT-4 cells. PZ671 effectively inhibits tumor growth and rapidly reverses transient platelet counts reduction in MOLT-4 xenograft mice. PZ671 can be used for the research of cancer, such as small cell lung cancer (SCLC)[1]. (Structure Note: Pink: Bcl-xL ligand (HY-174878), Blue: CRBN Ligand (HY-138793), Black: linker, E3-linker (HY-174879))
Molekulargewicht:
1335.02
Reinheit:
98.70
Formel:
C66H79ClF3N7O11S3
Target-Kategorie:
Apoptosis,Bcl-2 Family,PROTACs
Anwendungsbeschreibung:
MCE Product type: Reference compound1
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
