FHND5032 is an orally active miR-124 inducer. FHND5032 significantly upregulates miR-124 expression in macrophages. FHND5032 disrupts inflammatory signaling, promotes macrophage reprogramming, and restores the epithelial barrier function by inhibiting the PIK3R2/PI3K/Akt axis. FHND5032 alleviates colitis and reduces inflammatory burden in ulcerative colitis mice. FHND5032 can be used for the study of ulcerative colitis[1].
Molekulargewicht:
339.70
Reinheit:
99.49
CAS Nummer:
[3076057-63-8]
Formel:
C15H9ClF3N3O
Target-Kategorie:
Akt,Bacterial,Interleukin Related,PI3K
Anwendungsbeschreibung:
MCE Product type: Reference compound
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