D1/D5 Receptor agonist-1 is a highly brain-penetrant and orally active D1/D5 receptor agonist. D1/D5 Receptor agonist-1 maintains considerable efficacy in the cAMP pathway and in beta-arrestin recruitment, with EC50s of 3.7 nM (D1R cAMP), 91 nM (D1R beta-arrestin), 129 nM (D1R internalization) and a Ki of 111 nM (D1R binding affinity). D1/D5 Receptor agonist-1 inhibits beta-arrestin signaling in a rat with L-DOPA (HY-N0304) induced dyskinesias. D1/D5 Receptor agonist-1 can be used for the study of Parkinsons disease[1].
Molekulargewicht:
368.32
Formel:
C18H13FN4O4
Target-Kategorie:
Arrestin,Dopamine Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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