NADH-IN-3 (Compound C4-1) is a NADH inhibitor with a MIC of 4 µg/mL (13.042 µM) for type II NADH dehydrogenase of Mycobacterium tuberculosis (Mtb). NADH-IN-3 significantly interrupts ATP synthesis, shows potent inhibitory effects against mono (Rifampicin (HY-B0272) and Isoniazid (HY-B0329)) and multi drug-resistant (Mtb) strains and an anti-bactericidal activity against HepG2 cells with low cytotoxicity (SI: 16.52)[1].
Molekulargewicht:
306.45
Formel:
C15H18N2OS2
Target-Kategorie:
Endogenous Metabolite
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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