MP1202 is a dual-functional agonist of MOR and KOR with EC50s of 0.32 and 0.13 µM for mMOR-1 and mKOR-1, respectively. MP1202 has functional selectivity with reduction of beta-arrestin1/2 recruitment but significant activation of G-protein and Galpha-subtype at hMOR and hKOR. MP1202 has potent antinociceptive effects without typical opioid side effects, but it shows conditioned place preference and aversion behaviors in subtype-selective opioid KO mice model, promising for analgesia research[1].
Molekulargewicht:
556.44
CAS Nummer:
[2578974-82-8]
Formel:
C27H29IN2O3
Target-Kategorie:
Arrestin,Opioid Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound1
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
