SOS1-IN-20 (Compound 12f) is an orally active SOS1 inhibitor with an IC50 of 5.11 nM against KRASG12C::SOS1. By disrupting the interaction between KRAS and SOS1, SOS1-IN-20 inhibits KRAS activation and downstream signal transduction. SOS1-IN-20 has an IC50 of 253 nM for p-ERK in PC-9 cells and 16.71 µM for hERG channel . SOS1-IN-20 can inhibit the proliferation of tumor cells and has antitumor activity[1].
Molekulargewicht:
404.43
Formel:
C21H23F3N4O
Target-Kategorie:
Potassium Channel,Ras,SOS1
Anwendungsbeschreibung:
MCE Product type: Reference compound
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