(2S,3R,4S)-ASX-173, CAS [[2748800-07-7]]

Produktübersicht

• Artikelname: (2S,3R,4S)-ASX-173, CAS [[2748800-07-7]]
• Artikelnummer: MCE-HY-175282A
• Hersteller Artikelnummer: HY-175282A
• Alternativnummer: MCE-HY-175282A-25MG,MCE-HY-175282A-10MG,MCE-HY-175282A-5MG,MCE-HY-175282A-50MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

(2S,3R,4S)-ASX-173 is the (2S,3R,4S)-enantiomer of ASX-173 (HY-175282). ASX-173 is an orally active inhibitor of asparagine synthetase (ASNS) (IC50 = 0.113 µM, Ki = 0.4 nM). ASX-173 enhances the anticancer activity of L-asparaginase (ASNase) (HY-P1923). ASX-173 disrupts nucleotide synthesis and induces leukemia cell cycle arrest, apoptosis and autophagy in leukemia cells in combination with ASNase. ASX-173 slows the growth of OCI-AML2 xenografts in combination with ASNase. ASX-173 is indicated for the study of acute lymphoblastic leukemia, acute myeloid leukemia, colorectal cancer, and other cancers[1].

Produkteigenschaften

• Molekulargewicht: 475.55
• Reinheit: 99.29
• CAS Nummer: [2748800-07-7]
• Formel: C28H30FN3O3
• Target-Kategorie: Apoptosis,Autophagy,Caspase,CDK,PARP

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound